Job Description

Associate Scientist - iPSC-Derived Neuron Models

12 month contract

On-site in Lexington, MA

Must be able to work on a W2

JOB DESCRIPTION:

Position Summary:

We are seeking a highly motivated and detail-oriented scientist to join our Humanized In Vitro Model Development team. The successful candidate will contribute to the development of human iPSC-derived neuronal models and assays to support drug discovery and translational research. This is an exciting opportunity to work at the forefront of human-relevant neuroscience in a collaborative and innovative environment.

TOP SKILLS:

1. Human iPSC-derived neuron culture experience

2. Gene perturbations using siRNA and/or CRISPR

3. Cell-based molecular and biochemical assays including 1) immunocytochemistry, 2) qPCR, 3) ELISA, 4) micro-electrode array (MEA), and 5) fluorescence microscopy (at least 2-3 of these 5 skillsets).

Key Responsibilities:

• Culture, differentiate, and maintain human iPSC-derived neurons.

• Perform routine cell-based and molecular assays including immunocytochemistry, qPCR, ELISA, MEA, luciferase, western blot, and fluorescence microscopy.

• Conduct functional gene perturbations and pharmacological interventions.

• Support assay development and optimization for phenotypic screening and mechanistic studies.

• Analyze and interpret experimental data, maintain accurate records, and present findings in team meetings.

• Collaborate cross-functionally with scientists in different units.

• Contribute to protocol development, SOP documentation, and continuous improvement initiatives.

Qualifications:

• Bachelor’s or Master’s degree in Neuroscience, Cell Biology, Stem Cell Biology, or a related field.

• LEVEL II - Minimum of 2 years of hands-on experience with human iPSC-derived neuronal cell models and assays.

• LEVEL III - Minimum of 5 years of hands-on experience with human iPSC-derived neuronal cell models and assays.

• Proficiency in cell-based assay techniques and fluorescence microscopy.

• Strong organizational and communication skills.

• Ability to work independently and collaboratively in a fast-paced research environment.

• Comfortable working with electronic lab notebooks.

Preferred Skills:

• Experience with CRISPR editing, RNA-seq, calcium imaging, high-content imaging, or complex co-culture systems is plus.

• Knowledge of automated liquid handling systems and high-throughput screening platforms.

• Familiarity with cardiometabolic diseases is a plus.

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